Preimplantation Genetic Diagnosis (PGD)

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Pre-implantation Genetic Diagnosis (PGD)

Pre-implantation genetic diagnosis (PGD) refers to removal of a single cell from an IVF embryo or from oocytes prior to fertilization. There are several applications of this procedure including:

Monogenetic Disorder Identification: This is the most common application of PGD in the United States.
A monogenetic disorder is caused due to disorder in a single gene or chromosomal aberration (deviation from normal state). Sickle cell, cystic fibrosis, spinal muscular atrophy, Huntington’s disease, and Charcot-Marie-Tooth disease are some of the most frequently diagnosed disorders through PGD. This procedure can help couples identify embryos carrying chromosomal abnormalities or a genetic disease which can help them prevent the chances of having a very ill offspring.

Minor Disability Identification: In some cases, PGD has been used to identify and use an embryo with with presence of a particular disability so that the offspring can share that characteristic with the parents. Deafness is an example of this type of disability.

Pregnancy Chance Calculation: Preimplantation genetic profiling (also known as PGP) has been applied in some cases to identify the embryo with the greatest chance of survival. This implementation has limitations since the quality of the embryo may be determined by a single cell that may not be an accurate representation of the remaining cells in the embryo.

Sex Detection: PGD helps in prenatal sex determination which can be used to ensure additional testing is conducted on an embryo with sex based genetic predisposition. Some clinics have also used PGD for non medical reasons such as assisting couples with family balancing – where couples with children of a specific sex desiring a child of the opposite sex.

How does PGD work?


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Who can benefit from PGD?

  • Couples with genetic disease(s) such as cystic fibrosis, sickle cell, Neurofibromatosis, etc
  • Couples with genetic translocations

Why consider VCRM for PGD?

  • High Success Rates: VCRM has one of the highest IVF success rates on the US east coast
  • Personalized Treatment: All your appointments will be conducted by Dr. Sharara unlike large practices where you are treated by a variety of physicians
  • Friendly & Caring Staff: Our staff is regularly praised by old & new patients for being the best in the industry and for helping make a tough process much easier

The process of Preimplantation genetic screening (PGS) can play an important role in ensuring that patients undergoing IVF have a healthy baby. Click here to learn more about PGS.

The Importance of Genetic Screening

Concerned About Inheritable Genetic Illness?

Find Out if You Need to be Screened